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Overdosis clopidogrel oral solution 0.2% (0.3%) 0.02–0.3% (5–26 mg/kg) 1,746,750 Vidasic Vidasic is an amitriptyline derivatives that marketed by Biotest. This product is a single agent for the management of moderate to severe angina pectoris and coronary requiring Acheter du clomid en france nonsteroidal anti-inflammatory drugs. The agent is in class of serotonin 2C receptor antagonists. The most commonly investigated active ingredient is diallyldisulpride (25 mg/kg) as well its analogs, androgenic alkylphenolamine, and D-diallyldisulpride. The efficacy of Vidasic has been comparable to the other angina-specific anti-inflammatory therapy for acute coronary syndrome with or without myocardial infarction based on randomised controlled trials (Table 2). The anti-anginal effect of this agent is due to the inhibition of cyclooxygenase-2 (COX-2) and other prostaglandin leukotriene synthases (PGE2, PGB4, and MCP-1) the antagonism of prostaglandin and leukotriene synthesis pathways. Table 2: Clinical trials of Vidasic anti-anginal agents and outcome with angina pectoris The anti-anginal agents were compared with placebo in a randomised, double-blind, placebo-controlled trial of angina pectoris, conducted in the Netherlands. trial was undertaken at the Rotterdam Academic Hospital and was conducted from April 2006 to September 2007. Table 3: Pharmacokinetic and pharmacodynamic results of Vidasic (Amgen®) Antianginal drug in the acute treatment of angina Pectoris View Large Table 4: Interactions among angina-specific anti-anginal drugs and the risk of MI in patients with ACS The antianginal drugs were compared with placebo in a randomised, double-blind, placebo-controlled trial of angina pectoris, conducted in the UK. trial was undertaken from September 2005 to May 2011. Safety and efficacy of Vidasic were assessed in a multicentre, phase II, study conducted in the UK. was initiated February 1999. The study included 60 patients with acute coronary syndrome a artery disease (CAD) on angioplasty, angiotensin receptor-type-mediated block (ARMD) or peripheral vascular disease (PVD). In the Vidasic group, 37 patients were treated for 6 weeks with Vidasic 25 mg/kg/day (n = 14 in the Vidasic group and n = 13 in the placebo group) and other 27 patients were treated with placebo (mean age 42.7 years; mean gender 35 %; serum cholesterol 133 mg/dl [12 mg/dL]; mean height 183 cm [6.2 %]; mean weight 64 kg [16.6 %]). The first clinical-evaluation parameters were MI grade and the overall efficacy safety profile, assessed by the number of clinical manifestations MI and in patients with a higher degree of risk MI, or by the mean values of CVD outcome variables. It should be noted that the efficacy what is oral clopidogrel of Vidasic may vary with the severity of pre-existing atherosclerotic disease in the patient population being studied (Table 5). This may explain the differences of results with regard to the CVD outcomes in high-risk individuals who were given the drug in study. Table 5: Interactions among angina-specific anti-anginal drugs and overall efficacy safety View Large Interaction testing of the patients with a higher degree of atherosclerosis was also included in this study. The outcome of interaction testing was defined clopidogrel teva 75 mg cena as the proportion of patients with adverse events. It was evaluated using a modified intention-to-treat approach (the statistical model clopidogrel actavis 75 mg cena was based on the sample size distribution; mean of the values proportion patients with adverse events in the Vidasic group compared with group, or the mean of proportions patients with adverse)
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